After years of trying to discover how obesity could be an independent risk factor for the development of heart failure but somehow linked to improved survival among these patients, researchers have concluded that BMI obesity no longer appeared to hold counterintuitive protective effects after comprehensive adjustment for natriuretic peptides and other prognostic variables.

Their present findings result from a post-hoc analysis based on PARADIGM, a large multinational trial of more than 8 000 people with heart failure with reduced ejection fraction (HFrEF).

Eliminating this so-called “obesity paradox”, researchers found that study participants with the highest BMIs actually had excess combined heart failure hospitalisations and cardiovascular deaths, according to Dr John McMurray of British Heart Foundation Cardiovascular Research CentreUniversity of Glasgow, and colleagues…..more