The recent authorization by regulatory agencies across the world to distribute and administer COVID-19 vaccines marks an important turning point in the pandemic. The unprecedented attempt to achieve widescale vaccine coverage, however, has been met with an onslaught of false and misleading information. Misinformation has the potential to adversely affect vaccine uptake. For example, almost 40% of Americans now say they would not get the vaccine and a recent study found that belief in COVID-19 misinformation significantly reduced willingness to get the vaccine. Accordingly, it is critical to ramp up defenses against the on-going wave of COVID-19 vaccine misinformation and utilize effective strategies aimed at curbing its influence. A common method to combat vaccine misinformation involves debunking false claims. Though seemingly intuitive, research has found that this approach can exacerbate, rather than correct, the negative effects of misinformation. This is because corrections directly refuting misinformation can trigger the “continued influence effect,” whereby people continue to retrieve misinformation from memory even when acknowledging the correction. Furthermore, corrections can trigger psychological resistance, especially when corrections are perceived as attacking salient values and ideologies with which misinformation can resonate. For example, with public attitudes toward a COVID-19 vaccine becoming politically polarized, particularly in the U.S., misinformation corrections might be ineffective or potentially backfire among hesitant audiences, thus making vaccine misinformation even more influential in decision-making…more